Abstract: The utility of the adenosine deaminase (ADA) assay in the diagnosis of patients with pleural\ntuberculosis (TB) and human immunodeficiency virus (HIV) infection is controversial. Forty-eight\nHIV positive patients with pleural effusion were evaluated; ADA assay was obtained in forty-three\nof them. Twenty-five patients presented diagnosis of TB. Patients with diagnosis of TB showed a\nmedian value of ADA of 70 IU/L (interquartile range (IQR) 41â??89) and the non-TB group a median\nof 27.5 IU/L (IQR 13.5â??52). Patients with diagnosis of TB had a median cluster of differentiation 4\n(CD4) count of 174 (IQR 86â??274) and the non-TB group had a median of 134 (IQR 71â??371). Receiver\noperating characteristic curve was performed with an area under the curve of 0.79. The best cut-off\nobtained was 35 IU/L with a sensibility of 80% and a specificity of 66%. There was no correlation\nbetween CD4 lymphocytes count and the value of ADA in the TB patient group.
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